Protein name:
Insulin receptor substrate 2 (IRS-2) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with PHIP.
Function:
May mediate the control of various cellular processes by insulin.
Subcellular Location:
Cytoplasm
cytosol
Protein Attributes:
50:
MASPPRHGPP | GPASGDGPNL | NNNNNNNNHS | VRKCGYLRKQ | KHGHKRFFVL |
100:
RGPGAGGDEA | TAGGGSAPQP | PRLEYYESEK | KWRSKAGAPK | RVIALDCCLN |
150:
INKRADAKHK | YLIALYTKDE | YFAVAAENEQ | EQEGWYRALT | DLVSEGRAAA |
200:
GDAPPAAAPA | ASCSASLPGA | LGGSAGAAGA | EDSYGLVAPA | TAAYREVWQV |
250:
NLKPKGLGQS | KNLTGVYRLC | LSARTIGFVK | LNCEQPSVTL | QLMNIRRCGH |
300:
SDSFFFIEVG | RSAVTGPGEL | WMQADDSVVA | QNIHETILEA | MKALKELFEF |
350:
RPRSKSQSSG | SSATHPISVP | GARRHHHLVN | LPPSQTGLVR | RSRTDSLAAT |
400:
PPAAKCSSCR | VRTASEGDGG | AAAGAAAAGA | RPVSVAGSPL | SPGPVRAPLS |
450:
RSHTLSGGCG | GRGSKVALLP | AGGALQHSRS | MSMPVAHSPP | AATSPGSLSS |
500:
SSGHGSGSYP | PPPGPHPPLP | HPLHHGPGQR | PSSGSASASG | SPSDPGFMSL |
550:
DEYGSSPGDL | RAFCSHRSNT | PESIAETPPA | RDGGGGGEFY | GYMTMDRPLS |
600:
HCGRSYRRVS | GDAAQDLDRG | LRKRTYSLTT | PARQRPVPQP | SSASLDEYTL |
650:
MRATFSGSAG | RLCPSCPASS | PKVAYHPYPE | DYGDIEIGSH | RSSSSNLGAD |
700:
DGYMPMTPGA | ALAGSGSGSC | RSDDYMPMSP | ASVSAPKQIL | QPRAAAAAAA |
750:
AVPSAGPAGP | APTSAAGRTF | PASGGGYKAS | SPAESSPEDS | GYMRMWCGSK |
800:
LSMEHADGKL | LPNGDYLNVS | PSDAVTTGTP | PDFFSAALHP | GGEPLRGVPG |
850:
CCYSSLPRSY | KAPYTCGGDS | DQYVLMSSPV | GRILEEERLE | PQATPGPSQA |
900:
ASAFGAGPTQ | PPHPVVPSPV | RPSGGRPEGF | LGQRGRAVRP | TRLSLEGLPS |
950:
LPSMHEYPLP | PEPKSPGEYI | NIDFGEPGAR | LSPPAPPLLA | SAASSSSLLS |
1000:
ASSPASSLGS | GTPGTSSDSR | QRSPLSDYMN | LDFSSPKSPK | PGAPSGHPVG |
1050:
SLDGLLSPEA | SSPYPPLPPR | PSASPSSSLQ | PPPPPPAPGE | LYRLPPASAV |
1100:
ATAQGPGAAS | SLSSDTGDNG | DYTEMAFGVA | ATPPQPIAAP | PKPEAARVAS |
1150:
PTSGVKRLSL | MEQVSGVEAF | LQASQPPDPH | RGAKVIRADP | QGGRRRHSSE |
1200:
TFSSTTTVTP | VSPSFAHNPK | RHNSASVENV | SLRKSSEGGV | GVGPGGGDEP |
1250:
PTSPRQLQPA | PPLAPQGRPW | TPGQPGGLVG | CPGSGGSPMR | RETSAGFQNG |
1300:
LNYIAIDVRE | EPGLPPQPQP | PPPPLPQPGD | KSSWGRTRSL | GGLISAVGVG |
1338:
STGGGCGGPG | PGALPPANTY | ASIDFLSHHL | KEATIVKE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human IRS-2
ELISA Kit for Human IRS-2
Polyclonal Antibody for Human IRS-2
Polyclonal Antibody for Human IRS-2
Monoclonal Antibody for Human IRS-2
Monoclonal Antibody for Human IRS-2
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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Recovery
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Linearity
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References
1.
"14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain."
Ogihara T.
,
Isobe T.
,
Ichimura T.
,
Taoka M.
,
Funaki M.
,
Sakoda H.
,
Onishi Y.
,
Inukai K.
,
Anai M.
,
Fukushima Y.
,
Kikuchi M.
,
Yazaki Y.
,
Oka Y.
,
Asano T.
J. Biol. Chem.272:25267-25274(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
"Insulin receptor substrate 2 gene sequence."
Heyne B.
Submitted (2000-11) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.
"The DNA sequence and analysis of human chromosome 13."
Dunham A.
,
Matthews L.H.
,
Burton J.
,
Ashurst J.L.
,
Howe K.L.
,
Ashcroft K.J.
,
Beare D.M.
,
Burford D.C.
,
Hunt S.E.
,
Griffiths-Jones S.
,
Jones M.C.
,
Keenan S.J.
,
Oliver K.
,
Scott C.E.
,
Ainscough R.
,
Almeida J.P.
,
Ambrose K.D.
,
Andrews D.T.
,
Ashwell R.I.S.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Bannerjee R.
,
Barlow K.F.
,
Bates K.
,
Beasley H.
,
Bird C.P.
,
Bray-Allen S.
,
Brown A.J.
,
Brown J.Y.
,
Burrill W.
,
Carder C.
,
Carter N.P.
,
Chapman J.C.
,
Clamp M.E.
,
Clark S.Y.
,
Clarke G.
,
Clee C.M.
,
Clegg S.C.
,
Cobley V.
,
Collins J.E.
,
Corby N.
,
Coville G.J.
,
Deloukas P.
,
Dhami P.
,
Dunham I.
,
Dunn M.
,
Earthrowl M.E.
,
Ellington A.G.
,
Faulkner L.
,
Frankish A.G.
,
Frankland J.
,
French L.
,
Garner P.
,
Garnett J.
,
Gilbert J.G.R.
,
Gilson C.J.
,
Ghori J.
,
Grafham D.V.
,
Gribble S.M.
,
Griffiths C.
,
Hall R.E.
,
Hammond S.
,
Harley J.L.
,
Hart E.A.
,
Heath P.D.
,
Howden P.J.
,
Huckle E.J.
,
Hunt P.J.
,
Hunt A.R.
,
Johnson C.
,
Johnson D.
,
Kay M.
,
Kimberley A.M.
,
King A.
,
Laird G.K.
,
Langford C.J.
,
Lawlor S.
,
Leongamornlert D.A.
,
Lloyd D.M.
,
Lloyd C.
,
Loveland J.E.
,
Lovell J.
,
Martin S.
,
Mashreghi-Mohammadi M.
,
McLaren S.J.
,
McMurray A.
,
Milne S.
,
Moore M.J.F.
,
Nickerson T.
,
Palmer S.A.
,
Pearce A.V.
,
Peck A.I.
,
Pelan S.
,
Phillimore B.
,
Porter K.M.
,
Rice C.M.
,
Searle S.
,
Sehra H.K.
,
Shownkeen R.
,
Skuce C.D.
,
Smith M.
,
Steward C.A.
,
Sycamore N.
,
Tester J.
,
Thomas D.W.
,
Tracey A.
,
Tromans A.
,
Tubby B.
,
Wall M.
,
Wallis J.M.
,
West A.P.
,
Whitehead S.L.
,
Willey D.L.
,
Wilming L.
,
Wray P.W.
,
Wright M.W.
,
Young L.
,
Coulson A.
,
Durbin R.M.
,
Hubbard T.
,
Sulston J.E.
,
Beck S.
,
Bentley D.R.
,
Rogers J.
,
Ross M.T.
more...
Nature428:522-528(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
"Two missense mutations in insulin receptor substrate 2 (G879S and G882A)."
Heyne B.
,
Gehrisch S.
,
Jaross W.
Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE OF 1-1337;VARIANTS SER-879 AND ALA-882
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-388; SER-391 AND SER-560;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-350 AND THR-527;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-915;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-388; SER-391 AND SER-915;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Platelet .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306; SER-346; THR-350; SER-365; SER-384; SER-388; SER-391; SER-523; THR-527; SER-577; THR-579; THR-580; SER-594; SER-608; SER-620; SER-679; SER-735; SER-736; SER-770; THR-779; SER-828; SER-915; SER-973; SER-1100; THR-1159; SER-1162; SER-1174; SER-1176 AND SER-1203;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-391;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306; SER-388; SER-391; SER-560; SER-594; TYR-675; SER-736; SER-915 AND SER-1176;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306; SER-560; SER-915; SER-973 AND SER-1176;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ASP-1057